Bleaching Activity of New 2-Phenylpyridazinones: Structure-Activity Relationship
نویسندگان
چکیده
New 2-phenylpyridazinones, analogs o f 4-chloro-5-methylamino-2-phenylpyridazin-3(2H)ones, were assayed for their phytotoxic activity to interfere with plant pigment formation. Six derivatives with — SCF3, — OCF2CH FCF3, — O CH F2, — CN, or — Br in meta position o f the phenyl ring exhibited similar or better bleaching activity than the m -CF3 analog (norflurazon). The activity is predominantly determined by positive a values and by lipophilicity o f the substituent. On the basis o f 11 analogs, a quantitative structure-activity relationship by a Hansch equation was accomplished with am and the lipophilicity parameter n as variables.
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